Her parents betrothed her to a pious youth, but he died before the marriage took place. Macrina then consecrated her virginity to God and lived a life of great asceticism. She remained living with her parents, helping to raise her younger siblings, directing the household servants, and supporting the family with her domestic skills. Among her siblings were St. Basil the Great and St. Gregory of Nyssa (who both became Cappadocian Fathers and Doctors of the Church) St. Peter of Sebaste, and St. Theosevia.
When their father died, Macrina became the main support for the family. It was Macrina who profoundly influenced the spiritual discipline of her younger brothers. When all her siblings were grown, Macrina convinced her mother to give up their family belongings, set their servants free, and convert their home into a monastery. Many of their servants joined them in this spiritual pursuit; they all lived together as a family, sharing all things in common. When her mother died, Macrina led the religious community. The biography of St. Macrina's life was written by her brother, St. Gregory.
