Following the instructions of the Virgin Mary received in a vision, Peregrine went to Siena and joined the Servites. It is believed that he never allowed himself to sit down for thirty years, while as far as possible, observing silence and solitude. Sometime later, Peregrine was sent to Forli to found a new house of the Servite Order. An ideal priest, he had a reputation for fervent preaching and being a good confessor.
When he was afflicted with cancer of the foot and amputation had been decided upon, he spent the night before the operation, in prayer. The following morning, he was completely cured. This miracle caused his reputation to become widespread.
He died in 1345 at the age of eighty-five, and he was canonized by Pope Benedict XIII in 1726. St. Peregrine, like St. Paul, was in open defiance of the Church as a youth. Once given the grace of conversion he became one of the great saints of his time. His great fervor and qualities as a confessor brought many back to the true Faith. Afflicted with cancer, Peregrine turned to God and was richly rewarded for his Faith, enabling him over many years to lead others to the truth.
He is the patron of cancer patients.